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COMPANY CONTACT: Cindy Presar, Investor Relations cpresar@cardiodynamics.com 800-778-4825 Ext. 1031 CardioDynamics Announces Publication of Multicenter Hypertension CONTROL Trial Published in Hypertension , an American Heart Association Journal SAN DIEGO—March 7, 2006--CardioDynamics (Nasdaq: CDIC), the innovator and leader of impedance cardiography (ICG) technology, today announced the publication of its multicenter, randomized trial called CONTROL (Consideration Of Noninvasive Hemodynamic Monitoring To Target Reduction Of Blood Pressure Levels). The article was published online in Hypertension , an American Heart Association journal, and the print version of the article will appear in the April edition of the journal. The study demonstrated that using the Company’s BioZ ® ICG to make drug decisions achieved 35% superiority in blood pressure control to ...

P & T D IGEST A PEER-REVIEWED COMPENDIUM OF FORMULARY CONSIDERATIONS • Prevalence and economic implications • Summary of JNC-7 guidelines • Trials underlying JNC-7 guidelines • Implications of uncontrolled hypertension • Drug-therapy review • Recommendations for combination therapy • NCQA standards and quality measurement • Adherence to therapy • Formulary status of antihypertensive agents Vol.12,No.8 August 2003 S U P P L E M E N T T O M A N A G E D Care Care H YPERTENSION Continuing education credit for physicians and pharmacists is sponsored byThe Chatham Institute This program is supported by an unrestricted educational grant from AstraZeneca Page 2 A Tool for Formulary ...

What is Apparent Mineralocorticoid Excess (AME)? • AME is characterized by early-onset hypertension , hypokalemia, and metabolic alkalosis in the presence of low plasma renin activity and low serum aldosterone and often leads to nephropathy, retinopathy, neuropathy, cardiovasular disease, or even death at a young age. 1 • AME can be effectively treated, allowing prevention or even reversion of end-organ damage. 1 • AME is caused by autosomal recessive loss-of-function mutations in the gene HSD11B2, which codes for the enzyme 11-ß-hydroxysteroid dehydrogenase type 2. 2 Reduced activity of this enzyme allows cortisol to activate the mineralocorticoid receptor and thus increase renal sodium re-absorption in a renin-angiotensin independent manner. 1 Why genetic testing? Genetic testing for mutations in HSD11B2 ...

BRITISH HYPERTENSION SOCIETY British Hypertension Society HYPERTENSION MASTERCLASS Wedneday 3 rd May 2006 International Centre for Circulatory Health (ICCH) Imperial College at St. Mary’s, Paddington, London 5 th British Hypertension Society HYPERTENSION MASTERCLASS Welcome Invitation The British Hypertension Society is pleased to invite you to attend the fifth in its series of Hypertension Masterclasses . This CPD-accredited educational programme is designed to cover specialist topics in the field of hypertension , and is designed for both clinical and basic science members of the BHS, as well as non-members. It is the intention of the Society that the Masterclasses will support future hypertension specialist accreditation by providing continual professional development, and for this ...

M AY 1, 2001 / V OLUME 63, N UMBER 9 www.aafp.org/afp A MERICAN F AMILY P HYSICIAN 1789 childhood, the condition affects both genders equally; after puberty, it is more common in women than in men (ratio: 1.7 to 1). Primary pulmonary hypertension is most prevalent in persons 20 to 40 years of age. The condition has no racial predilection. 1 Secondary pulmonary hypertension is rela- tively common but is underdiagnosed. Reli- able estimates of the prevalence of this condi- tion are difficult to obtain because of the diversity of identifiable causes. In persons more than 50 years of age, cor pulmonale, the consequence of untreated pulmonary hypertension , is the third most common cardiac disorder (after coronary and hypertensive heart disease). 2 ...

S EPTEMBER 1, 2003 / V OLUME 68, N UMBER 5 www.aafp.org/afp A MERICAN F AMILY P HYSICIAN 853 Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) and are summarized in Table 1 . 3 Advances in the management of hypertension have refined our under- standing of systolic blood pressure, nutri- tion, medication selection, and hyperten- sion in special populations. Systolic Blood Pressure Although physicians traditionally have emphasized management of diastolic blood pressure, 4 systolic blood pressure and pulse pressure (the difference be- tween systolic and diastolic pressures) correlate more strongly with cardiovas- cular disease risk than does diastolic blood pressure, and treatment of isolated ...

2006 CANADIAN HYPERTENSION EDUCATION PROGRAM RECOMMENDATIONS 2006 marks the seventh consecutive year that CHEP has updated recommendations for the diagnosis, management and treatment of hyper- tension. This year CHEP’s recommendations focused on adherence to anti-hypertensive ther- apy. THE NEW KEY MESSAGE OF THE 2006 RECOMMENDATIONS IMPROVE PATIENT ADHERENCE TO ANTI-HYPERTENSIVE THERAPIES. Adherence with anti-hypertensive management can be improved by implementing a multi- pronged approach including: A. Assist your patient to adhere. 1. Teach patients to take their pills on a regular schedule associated with a rou- tine daily activity (e.g. brushing teeth). 2. Simplify regimens using long-acting once-daily medications. 3. Utilize fixed-dose combination medica- tions. 4. Utilize unit-of-use packaging (e.g. blis- ter packaging). ...

2006 CANADIAN HYPERTENSION EDUCATION PROGRAM RECOMMENDATIONS SOUND BITE VERSION Hypertension remains a significant health problem that is projected to become a greater global burden in the next 20 years. The estimated total number of adults with hypertension in 2000 was 972 million; 333 million in economically developed countries and 639 million in less economically devel- oped countries. The number of adults with hypertension in 2025 is anticipated to in- crease by about 60% to a total of 1.56 bil- lion. Hence hypertension is an important and growing public health challenge world- wide. Prevention, detection, treatment, and control of this condition should receive high priority. The Canadian Hypertension Educa- tion Program (CHEP) has a mandate to im- prove the management of hypertension , to develop tools to aid health care profession- ...

Unrestricted Data and Business Rules – Established Hypertension Indicator Set Author Paul Amos Version No 8.5 Version Date 18-May-2006 New GMS Contract QOF Implementation Dataset and Business Rules - Established Hypertension Indicator Set Page 2 Unrestricted Hypertension ruleset_R4_v8.5 Version date: 18-May-2006 Amendment History: Version Date Amendment History 0.1 09-Jul-2004 From Peter Horsfield. Extracted from July Read Code Release. Contains Read v0 only. 1.0 27-Sep-2004 Amended following 4 Country Review 1.1 18-Jan-2005 Amended following January READ Code Release 1.2 21-Jun-2005 Amended following 4 Country review 2.0 21-July-2005 Signed off following 4 Country review 2.1 21-July-2005 Amended following July 2005 Read Code ...

1. ISSUANCE: Monthly. 2. ESTABLISHED: 1983. 3. ORGANIZATION AFFILIATION: The International Society for Hypertension and the European Society of Hypertension . 4. SPECIAL ISSUES: Bonus distribution with the American College of Cardiology Convention issue published in March, and the American Heart Association Convention issue published in November. Bonus Distribution at International Society for Hypertension (held every even year) and European Society of Hypertension (held every year) meetings. 5. DESCRIPTION: The Journal of Hypertension consistently attracts the most important and highly innovative papers from the current research; our commitment to rapid publication ensures that these are published in the fastest time possible. In addition to primary papers from world-renowned experts, the journal contains authoritative reviews and guidelines on the ...

Biochemical markers of endothelial dysfunction in patients with endocrine and essential hypertension Petrák O., Widimský J.jr, Zelinka T., Kvasnicka J.*, Štrauch B., Holaj R., Štulc T., Kvasnicka T, Bílková J.*, Škrha J. III.rd Internal Department, * Central Hematology Laboratory , 1 st Medical Faculty, Charles University, General Facuty Hospital, Prague, Czech republic Page 2 Summary : Aim of the study was to evaluate potential differences in the concentration of biochemical markers of endothelial dysfunction (ED) between essential (EH), endocrine hypertension /pheochromocytoma (PHEO), primary hyperaldosteronism (PH)/ and control healthy group and to assess potential relationship between these markers of ED and vasopressor substances overproduced in endocrine hypertension . We have investigated 21 patients with moderate essential hypertension ...

Hypertension BMI Perc ent a ge 20 25 30 35 40 20 10 30 50 40 60 Relationship between BMI and crude percentage of women reporting medical problems, surgical procedures, symptoms, and health care utilization. Brown WJ et al. Int J Obes 1998;22:520-528. Page 2 BMI Perc ent a ge 20 25 30 35 40 0 10 5 15 Diabetes Brown WJ et al. Int J Obes 1998;22:520-528 . Relationship between BMI and crude percentage of women reporting medical problems, surgical procedures, symptoms, and health care utilization. Page 3 BMI Perc ent a ge 20 25 30 35 ...

HIGH BLOOD PRESSURE ( HYPERTENSION ) FACT SHEET Fast Facts on Hypertension Scope and Prevalence in the U.S.: • Hypertension is a major risk factor for heart disease, which is the leading cause of death in America. • Hypertension is the most common primary diagnosis in the US, accounting for over 10 million doctor visits per year. 1 • Approximately 30% of American adults (about 50 million people) have high blood pressure, also known as hypertension . 2 • Over half of Americans age 60 and older have high blood pressure. People with normal blood pressure at age 55 have a 90% risk of developing high blood pressure as they age. 3 • High blood pressure is often called the “silent killer” because it has no symptoms and because one-third of people with high blood pressure do not know they have the condition. 4 • In 2000, 118,000 Americans died of high ...

7 t h e r a p e u t i c s l e t t e r June 1995 W e are bombarded with suggestions as to what should be our drug of first choice in the management of patients with documented elevated blood pressure. Is it appropriate to choose randomly from the wide array of available drugs, or is there a way to rationally pick the drug which is most likely to benefit our patients? By setting up a hierarchy of the issues which are most important, and compiling and critically appraising the presently available evidence, it is possible to narrow the choice to one or two drugs (see picture). The issues that are signif- icant in descending order of importance include: evidence of effectiveness in decreasing the complica- tions associated with hypertension , efficacy in lowering blood pressure, tolerability, convenience of dosing, and cost. • What evidence ...

8a A fter review of the long term hypertension studies, including the epidemiologic and ran- domized placebo controlled drug trials, certain clinically important facts stand out: •Risk of cardiovascular events correlates better with systolic than diastolic blood pressure. 1 •Risk correlates better with blood pressures taken outside the doctor’s office than with office blood pressures. 2 •Blood pressure consistently decreases with placebo treatment (10/8 mm Hg). 3 •The average additional blood pressure fall in the active treatment group is modest (11/6 mm Hg). 3,4 •The average blood pressure fall with treatment in trials using low doses of just one drug (7-9.5/4- 6.5mm Hg) 5,6 is similar to that obtained from an overview of trials using high doses of multiple drugs (11/6 mm Hg). 3,4 ...

QUESTIONS Choose the single best answer for each question. 1. Which of the following statements regarding the epidemiology of essential (primary) hypertension in the United States is correct? A) Mexican American women have a higher prevalence of essential hypertension than do Mexican American men B) More women than men have essential hyper- tension C) Non-Hispanic black adults have a lower preva- lence of essential hypertension than do Mexican American adults D) Non-Hispanic white men have the lowest prevalence of essential hypertension E) The overall prevalence of essential hyperten- sion in Americans is approximately 20% 2. Which of the following statements about the caus- es of secondary hypertension is NOT true? A) Causes of secondary hypertension occur more frequently than do those of essential hyperten- sion B) Cocaine and methamphetamine ...

The World Hypertension Market 2005 - 2010 A visiongain Report © notice This material is copyright 2005 by visiongain. It is against the law to reproduce any of this material without the prior written agreement of visiongain. You cannot photocopy, fax, download to database or duplicate in any other way any of the material contained in this report. Each purchase and single copy is for personal use only. Page 2 The World Hypertension Market 2005 - 2010 1. Executive Summary - Hypertension is a Serious Cause of Mortality Worldwide The purpose of this market report is to examine the prospects of the world hypertension market, including a forecast of revenue potential for many of the leading products from 2005-2010. The hypertension market is one of the largest and most important in the pharmaceutical industry. Furthermore, the treatment of hypertension ...

TESTIMONY OF MR. CARL HICKS VICE PRESIDENT FOR ADVOCACY PULMONARY HYPERTENSION ASSOCIATION BEFORE THE HOUSE ENERGY AND COMMERCE SUBCOMMITTEE ON HEALTH “IMPROVING AMERICA’S HEALTH: EXAMINING FEDERAL RESEARCH EFFORTS FOR PULMONARY HYPERTENSION AND CHRONIC PAIN.” THURSDAY, DECEMBER 8, 2005 10:00AM SUMMARY OF TESTIMONY: 1) INTRODUCTION TO PULMONARY HYPERTENSION AND THE PULMONARY HYPERTENSION ASSOCIATION. 2) PERSONAL STORY OF MEAGHAN HICKS’ BATTLE WITH THE DISEASE. 3) DISCUSSION OF H.R. 3005, THE “PULMONARY HYPERTENSION RESEARCH ACT.” Page 2 2 Mr. Chairman, Congressman Brown and distinguished members of the subcommittee, thank you for convening this important hearing this morning and for the opportunity to testify. I am Carl Hicks, Vice President for Advocacy with the Pulmonary Hypertension ...

Hypertension Treatment Is it time for a change? Is today’s blood pressure at goal? Yes No Home-monitored blood pressure range / to / Hypertension Treatment Is it time for a change? Is today’s blood pressure at goal? Yes No Home-monitored blood pressure range / to / Hypertension Treatment Is it time for a change? Is today’s blood pressure at goal? Yes No Home-monitored blood pressure range / to / Hypertension Treatment Is it time for a change? Is today’s blood pressure at goal? Yes No Home-monitored blood pressure range / to / Hypertension Treatment Is it time for a change? Is today’s blood pressure at goal? Yes No Home-monitored blood pressure ...

Effects of Age and Hypertension Status on Cognition: The Veterans Affairs Normative Aging Study Christopher B. Brady Veterans Affairs Boston Healthcare System and Harvard Medical School Avron Spiro, III Veterans Affairs Boston Healthcare System and Boston University School of Public Health J. Michael Gaziano Veterans Affairs Boston Healthcare System and Harvard Medical School The authors examined the influence of age and hypertensive status (normotensive, controlled, untreated, or uncontrolled) on several cognitive tests via multiple regression in 357 nondemented, community- dwelling older men (mean age 67 years) whose hypertensive status was stable over 3 years and who had no medical comorbidities. Age was negatively associated with performance on all but 1 test. Age interacted with hypertensive status on verbal fluency and word list immediate recall; older uncontrolled ...

Message Cardiovascular diseases, such as ischaemic and hypertensive heart disease, stroke, rheumatic heart disease and inflammatory heart disease, account for 27% of all deaths and 10% of the disease burden in the WHO South-East Asia Region (SEAR). Almost half of the deaths due to chronic, noncommunicable diseases, including those related to cardiovascular diseases, occur prematurely. The invisible epidemic of cardiovascular diseases is progressing and threatening the progress in economic and social development of low and middle-income countries, where 80% of all global deaths due to chronic diseases occur. Large segments of populations in India and in other countries of the Region are increasingly exposed to man-made physical and socioeconomic environments that adversely affect health. Common modifiable risk factors arising from these determinants underpin the chronic disease epidemic in the ...

hypertension THE SOUTHERN AFRICAN HYPERTENSION SOCIETY invites you to the 2006 HYPERTENSION GUIDELINE WORKSHOP (CPD accredited - 5 points) Come and hear the experts! DATE: Saturday, 30 th September 2006 TIME: Registration from 09:00 09h30 to 15h30 VENUE: VW Conference Centre, Midrand PRESENTERS: Prof. John Milne and Prof. Joe Veriava PROGRAMME: BP measurement Assessing cardiovascular risk Routine investigations BP targets Deciding treatment on options using the new algorithm Compelling indications for certain medications Resistant (stage 3) hypertension Case studies will be used throughout to illustrate the guideline This workshop is sponsored by unrestricted educational grants from: ...

Hypertension A G UIDE FOR P ATIENTS May 2003 What is Hypertension ? Hypertension is the medical term for high blood pressure. Blood pressure refers to the force of blood against the blood vessel walls. Normally a person’s blood pressure rises and falls during the day. However, when blood pressure constantly stays higher than normal (140/90 mm Hg or higher), a person is considered to have hypertension . What Causes Hypertension ? For about 90-95% of people with mildly elevated blood pressure, sedentary lifestyle, smoking, excess abdominal weight, a fatty diet, alcohol consumption and stress contribute to the condition. For the other 5-10% of people, there may be a serious underlying cause of high blood pressure that requires urgent medical attention. Risk factors for developing hypertension that you cannot change are: • family history of hypertension ...

Part II: Treatment of Essential Hypertension Scope This guideline focuses on the treatment of essential hypertension (HT) in non-pregnant adults (aged 19 years and older). This guideline is to be used with “Part I: Detection and Diagnosis of Hypertension ”. R ECOMMENDATION 1: Standard of care • In the course of normal medical contact, people should have their blood pressure recorded once every two to five years commensurate with age. • Establish firm diagnosis and rule out underlying causes. • Identify those requiring immediate management. • Establish the patient’s role in managing their condition, review lifestyle modifications. • Establish the minimum dose of medication required to achieve the target BP (see table 1). Table 1: Blood pressure treatment targets * † * The benefits of initiating antihypertensive therapy when hypertension is first diagnosed after ...

H igh blood pressure, or hypertension , is very common in the UK - one in four adults suffer from it. It usually occurs as we get older and the walls of our blood vessels lose some of their elasticity and become rigid. Several aspects of your lifestyle, including diet, can cause this to happen more quickly. Untreated hypertension increases the risk of heart attacks and stroke as well as kidney and eye damage. The good news is that simple changes to your diet can be a very effective part of treatment. Should I cut down on salt? Yes. This can help reduce your blood pressure so it's well worth doing. Reducing the amount of salt (or sodium chloride) you add at the table and in cooking, perhaps making more use of herbs and spices, is a start. It doesn't take long before you barely notice it's missing and can enjoy the real flavour of your food. Some people ...

1 2/2005 Details of recommendations can be found in the main text at the pages indicated. C Grade hypertension according to systolic and diastolic BP levels. (pg 13) Grade C, Level IV C Use the following procedures when recording BP: • allow the patient to sit or lie down for several minutes before measuring the BP • the 30 minutes preceding the measurement • bladder for fat arms. least 80% of the arm. • diastolic BP • measure the BP in both arms at the first visit • take 2 or more readings separated by 2 minutes. should be obtained and averaged. MOH CLINICAL PRACTICE GUIDELINES Hypertension Executive summary of recommendations Definition of high blood pressure Evaluation of high blood pressure the patient ...

HYPERTENSION AWARENESS Were you ever told that your blood pressure was high? • In 1997, 23% of Montana adults had been told at some time by a health care professional that their blood pressure was high. • There was essentially no difference between sexes with respect to having been told they had high blood pressure. • The percentage of adults who had ever been told they had high blood pressure increased with increasing age class. Significantly more adults aged 65 and older were told they had high blood pressure than adults in younger age classes. • The percentage of adults reporting high blood pressure has remained approximately the same between 1991 and 1997. Have you had your blood pressure checked in the past two years? • Ninety-two percent of Montana adults in 1997 reported having had their blood pressure checked in the last two years. • Women were significantly ...

www.ahrq.gov The mission of AHRQ is to improve the quality, safety, efficiency, and effectiveness of health care by: • Using evidence to improve health care. • Improving health care outcomes through research. • Transforming research into practice. Background Nearly one in every five people in the United States—about 58 million Americans—suffers from high blood pressure ( hypertension ), making it the Nation’s most common medical condition. In 2001, hypertension was the primary diagnosis for some 35 million office visits. Almost one-third of those with high blood pressure are not aware they have it, and the risk of developing the condition increases with age. Defined as an elevation in systolic blood pressure greater than 140mm Hg, and/or an elevation in diastolic blood pressure greater than 90mm Hg, hypertension has ...

1 May 2003 The Canadian Hypertension Education Program Recommendations: what’s new, what’s old but still important in 2003. The Bottom Line Version On behalf of the Evidence Based Recommendations Task Force of the Canadian Hypertension Education Program Corresponding Author: Dr. Ross D Feldman Robarts Research Institute 100 Perth Drive Po Box 5015 London, Ontario, Canada N6A 5K8 feldmanr@lhsc.on.ca Page 2 2 Introduction This summary outlines the ongoing efforts of the majority of hypertension specialists in Canada to develop and update evidence-based recommendations for the management of hypertension . This effort, initiated on a yearly basis in 1999, represents much more than an academic exercise. It has clearly been recognized that our ability to influence health care professionals and improve the management of ...

OBJECTIVES To improve the treatment and control of hypertension in Canada through a health care professional education program (Canadian Hypertension Education Program (CHEP)). RESULTS Every year since 1999 there has been a comprehensive update to hypertension management recommendations in Canada. The knowledge transfer process has evolved into an extensive process that includes translation of the recommendations into simple clear messages and dissemination in a large variety of written formats and practical tools to facilitate decision making. The dissemination is done in an comprehensive manner by members of the Implementation Task Force through the CHEP web site (www. hypertension .ca), publication into peer-reviewed and non peer-reviewed journals and through Continuing Medical Education programs. Discipline specific work groups have been formed to ensure dissemination to Family Physicians, ...