[91]
2005 Canadian Hypertension Education Program Recommendations
[616,5 KB]
From [www.hypertension.ca] Last viewed: 21.09.2006
1
2005 Canadian Hypertension Education Program Recommendations
:
The bottom line version
On behalf of the Evidence-Based Recommendations Task Force of the
Canadian Hypertension Education Program
Page 2
2
2005 marks the sixth consecutive year that the Canadian Hypertension Education Program
has updated recommendations for the management of hypertension . The goal of this effort
has been two-fold: 1) to offer those in clinical practice a consensus view of how to manage
the more than 5 million Canadians with hypertension (based on a critical analysis of the most
recent clinical trials data in the field) and 2) to utilize these updates as an opportunity to
reiterate the key components of an optimal management program in hypertension . In some
ways, the most notable aspect of the 2005 process is the appreciation that despite the
advances made in the ...
[92]
2005 Canadian Hypertension Education Program Recommendations
[436,3 KB]
From [www.hypertension.ca] Last viewed: 21.09.2006
1
2005 Canadian Hypertension Education Program Recommendations
:
The sound bite version
On behalf of the Evidence-Based Recommendations Task Force of the
Canadian Hypertension Education Program
Page 2
2
2005 marks the sixth consecutive year that the Canadian Hypertension Education Program
has updated recommendations for the management of hypertension . This year we have
focused on the evidence supporting expedited assessment of both the hypertension -related
risk of atherosclerotic disease as well as a more “global” atherosclerotic risk assessment. In
addition, the 2005 recommendations support the increasingly held belief that, in the choice of
antihypertensive drugs, consideration of the effectiveness of blood pressure control
supersedes consideration of “pleiotropic” effects for the 5 major antihypertensive classes.
The new key messages identified ...
[93]
Paper 1004 Geographic Clustering of Obesity, Diabetes, and ...
[3466,0 KB]
From [gis.esri.com] Last viewed: 21.09.2006
AREA
Male
Female
Male
Female
Male
Female
Male
Female
Male
Female
Male
Female
Male
Female
NUMBER
RATE
yrs.
5 - 14
15 - 49
50 - 64
65 yrs.
NOTIFIABLE DISEASES: HYPERTENSION
By Health Region, Province & City
Philippines, 2002
By Age-Group and By Sex
TOTAL
BOTH SEXES
1 yr.
yrs.
TOTAL
& above
yrs.
yrs.
LESS THAN
1 - 4
PHILIPPINES
17
18
121
101
354
914
40,447
63,199
56,379
64,882
38,905
39,565
136,011
168,679
304,690
383.2
NAT. CAP. REGION
1
-
6
3
9
25
2,112
3,456
2,507
3,752
...
[94]
AMERICAN SOCIETY OF HYPERTENSION (ASH) CHAPTER APPLICATION ...
[14,9 KB]
From [www.ash-us.org] Last viewed: 21.09.2006
AMERICAN SOCIETY OF HYPERTENSION (ASH)
CHAPTER APPLICATION PROTOCOL
050930
1
1. Current members of the American Society of Hypertension , Inc. (ASH) have
the option of establishing a steering committee to explore the option of
establishing a new Regional Chapter of the American Society of Hypertension
in a region where none exists.
2. The steering committee must obtain signed petitions from at least twenty
current ASH Members who reside in the region of the proposed Chapter,
supporting the establishment of the new ASH Chapter and agreeing to abide
by Chapter licensing requirements.
3. In exploring this option, the steering committee will review the following
documents available from the ASH Office regarding the role and function of
ASH Chapters:
• ASH Chapter Mission & Purpose Statement
• ASH Chapter Bylaws template
• ASH Chapter ...
[95]
What is hypertension? Hypertension is another name for high blood ...
[327,7 KB]
From [www.ash-us.org] Last viewed: 21.09.2006
2
3
P A T I E N T
I N F O R M A T I O N
G U I D E
U N D E R S T A N D I N G
H Y P E R T E N S I O N
1
What is hypertension ?
Hypertension is another name for high blood pressure. It is a condition that
occurs when the pressure inside of your large arteries is too high. Because it is a
silent disorder, the only way to detect hypertension is to have your blood
pressure measured. Hypertension is a very common problem that affects about
50 million people in the United States alone. It is more common as people
grow older and is both more common and more serious in African Americans.
Hypertension is not simply being tense or nervous.
2
What causes hypertension ?
More than 9 of every 10 people who have hypertension do not have a cause for
it that can be identified. We do know that you can inherit the tendency to
hypertension ...
[96]
AMERICAN SOCIETY OF HYPERTENSION (ASH) CHAPTER LICENSING ...
[28,3 KB]
From [www.ash-us.org] Last viewed: 21.09.2006
AMERICAN SOCIETY OF HYPERTENSION (ASH)
CHAPTER LICENSING REQUIREMENTS
040506
1
In order to be licensed as a Regional Chapter of the American Society of Hypertension ,
Inc. (ASH), a Chapter must initially meet and maintain the following licensing
requirements. Failure to meet these licensing requirements and performance criteria
will constitute sufficient grounds for revocation of the Chapter license.
1. CHAPTER MISSION & PURPOSE STATEMENTS
ASH Chapters must adhere to the ASH Chapter Mission & Purpose Statement:
• The Chapters shall further the objectives of the American Society of
Hypertension , Inc. (ASH) by organizing and conducting educational
activities designed to promote and encourage the development,
advancement, and exchange of scientific information in all aspects
of research, diagnosis and treatment of hypertension , and ...
[97]
The Dietary Approaches to Stop Hypertension - Sodium Study (DASH ...
[78,5 KB]
From [www.nhlbi.nih.gov] Last viewed: 21.09.2006
The Dietary Approaches to Stop Hypertension - Sodium Study (DASH-Sodium)
Page 1 of 11
The Dietary Approaches to Stop Hypertension - Sodium Study (DASH-Sodium)
Data Distribution Agreement
The National Heart, Lung, and Blood Institute (NHLBI) and
(Name of Recipient Organization) hereby enter into this Distribution Agreement as of the date
specified on the final page hereof.
PRELIMINARY STATEMENT
The National Heart, Lung, and Blood Institute (NHLBI) has supported collection of data from
participants in The Dietary Approaches to Stop Hypertension - Sodium Study (DASH-Sodium),
hereafter referred to as “Study”. This well-characterized population provides a rare and valuable
scientific resource. Promoting optimal use on a national scale of such a resource will require a
large and concerted effort which may exceed the research capacity of currently available Study
investigators. The NHLBI and the researchers ...
[98]
Dietary Approaches to Stop Hypertension (DASH) Data Distribution ...
[77,1 KB]
From [www.nhlbi.nih.gov] Last viewed: 21.09.2006
The Dietary Approaches to Stop Hypertension study (DASH)
Page 1 of 11
Dietary Approaches to Stop Hypertension (DASH)
Data Distribution Agreement
The National Heart, Lung, and Blood Institute (NHLBI) and
(Name of Recipient Organization) hereby enter into this Distribution Agreement as of the date
specified on the final page hereof.
PRELIMINARY STATEMENT
The National Heart, Lung, and Blood Institute (NHLBI) has supported collection of data from
participants in the Dietary Approaches to Stop Hypertension (DASH), hereafter referred to as
“Study”. This well-characterized population provides a rare and valuable scientific resource.
Promoting optimal use on a national scale of such a resource will require a large and concerted
effort which may exceed the research capacity of currently available Study investigators. The
NHLBI and the researchers it supports have a responsibility to the public in general, ...
[99]
The Patient Registry for Primary Pulmonary Hypertension (PPH ...
[79,1 KB]
From [www.nhlbi.nih.gov] Last viewed: 21.09.2006
The Patient Registry for Primary Pulmonary Hypertension (PPH Registry)
Page 1 of 12
The Patient Registry for Primary Pulmonary Hypertension (PPH Registry)
Data Distribution Agreement
The National Heart, Lung, and Blood Institute (NHLBI) and
(Name of Recipient Organization) hereby enter into this Distribution Agreement as of the date
specified on the final page hereof.
PRELIMINARY STATEMENT
The National Heart, Lung, and Blood Institute (NHLBI) has supported collection of data from
participants in The Patient Registry for Primary Pulmonary Hypertension (PPH Registry),
hereafter referred to as “Study”. This well-characterized population provides a rare and valuable
scientific resource. Promoting optimal use on a national scale of such a resource will require a
large and concerted effort which may exceed the research capacity of currently available Study
investigators. The NHLBI and the researchers ...
[100]
CHI Hypertension
[541,6 KB]
From [www.nyc.gov] Last viewed: 21.09.2006
TABLE 1. CLASSIFICATION OF BLOOD
PRESSURE LEVELS FOR PEOPLE
18 AND OLDER*
Systolic BP
Diastolic BP
(mm Hg)
(mm Hg)
Normal
<120
AND
<80
Pre- Hypertension ** 120 to 139 OR
80 to 89
Stage 1
140 to 159 OR
90 to 99
Hypertension
Stage 2
=160
OR
=100
Hypertension
* Based on the average of 2 or more correctly measured,
seated readings taken on each of 2 or more office visits
** New category introduced in JNC-7 Report
Adapted from: JNC-7, National Heart, Lung, and Blood Institute
5
October 2005
Vol. 24(7):39-50
U
ncontrolled hypertension is a leading cause of
preventable heart attack, stroke and death.
The risk of death from cardiovascular disease
and stroke begins to rise at levels as ...
[101]
Hypertension
[271,7 KB]
From [hp2010.nhlbihin.net] Last viewed: 21.09.2006
Hypertension
BMI
Perc
ent
a
ge
20
25
30
35
40
20
10
30
50
40
60
Relationship between BMI and crude percentage of women reporting
medical problems, surgical procedures, symptoms, and health care utilization.
Brown WJ et al. Int J Obes 1998;22:520-528.
Page 2
BMI
Perc
ent
a
ge
20
25
30
35
40
0
10
5
15
Diabetes
Brown WJ et al. Int J Obes 1998;22:520-528
.
Relationship between BMI and crude percentage of women reporting
medical problems, surgical procedures, symptoms, and health care utilization.
Page 3
BMI
Perc
ent
a
ge
20
25
30
35 ...
[102]
Chronic Hypertension in Pregnancy
[44,1 KB]
From [hp2010.nhlbihin.net] Last viewed: 21.09.2006
Prepregnancy counseling:
• Evaluate using JNC VI criteria
• Discontinue use of ACE inhibitors and ARBs
• Evaluate for target organ damage in women with
longstanding hypertension
• Discontinue use of tobacco and/or alcohol, even
if not hypertensive
• Discuss lifestyle changes, if applicable
Chronic Hypertension in
Pregnancy
Page 2
Category
SBP
(mm Hg)
DBP
(mm Hg)
Optimal
< 120
and
< 80
Normal
< 130
and
< 85
High-normal
130–139
or
85–89
Hypertension
Stage 1
Stage 2
Stage 3
140–159
160–179
= 180
or
or
or
90–99
100–109
> 110
When SBP and DBP fall into different categories, use the higher category
.
JNC VI Classification of
Blood Pressure for Adults ...
[103]
2005 HYPERTENSION GL.xls
[28,0 KB]
From [www.mcare.org] Last viewed: 21.09.2006
August 2005
Eligible Population
Key Components
Initial assessment
Patient education and
nonpharmacologic
interventions
Goals of Therapy
Pharmacologic
interventions
Monitoring and
adjustment of therapy
[D]
Approved by MQIC Medical Directors 08/05
www.mqic.org
This guideline represents core management steps. It is based on the 2003 Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure
(www.nhlbi.nih.gov). Individual patient considerations and advances in medical science may supersede or modify these recommendations.
Michigan Quality Improvement Consortium Guideline
Medical Management of Adults with Hypertension
The following guideline recommends diagnostic evaluation, education and pharmacologic treatment that support effective patient self-management.
Recommendation ...
[104]
Hypertension
[167,8 KB]
From [shs.sdsu.edu] Last viewed: 21.09.2006
Blood Pressure
Blood pressure is a measure of the force which is exerted
by the blood on the walls of the arteries as the heart
pumps it through the body. This pressure is expressed
as two numbers, for example 120/80. The first number is
the systolic pressure, the pressure inside the arteries
when the heart is contracting. The second number is the
diastolic pressure, the pressure level during the time the
heart muscle is relaxing.
Normal Readings
Health care providers consider the average range for
blood pressure to be from 90-140 systolic, and from 60-
90 diastolic. An average optimum level is 120/80 or less.
Blood pressure is generally viewed as high if it is consis-
tently above 140 systolic and 90 diastolic. If you have
several readings above 140/90 you should be evaluated
by a medical provider.
NOTE
A single elevated blood pressure reading DOES NOT
mean you ...
[105]
1 A Report on World Hypertension Day in Isfahan-Iran
[112,4 KB]
From [www.hbi.ir] Last viewed: 21.09.2006
1
A Report on World Hypertension Day in Isfahan-Iran
May 14
th
2005
Isfahan Province is located in central Iran and has a population of 2 million. A recent report as
part of IHHP (Isfahan Healthy Heart Project), a national plan for chronic disease prevention
and control ( www.ihhp.mui.ac.ir ) showed that the prevalence of hypertension in Isfahan is
18%, but only 12% of hypertensive patients were well controlled. Studies conducted by
Isfahan Cardiovascular Research Center (ICRC) have revealed that public awareness of
hypertension and its treatment has increased from 28% to 51% during the last decade. To
improve the public knowledge on the World Hypertension Day on May 14
th
2005, the
Scientific Committee of High Blood Pressure of the Iranian Heart Foundation
( www.hbi.ir/hosting/ihf/ihf.htm ), and the Hypertension Unit of Isfahan Cardiovascular
Research ...
[106]
DRUGS USED TO TREAT HYPERTENSION There are many drugs that can be ...
[19,3 KB]
From [www.southalabama.edu] Last viewed: 21.09.2006
DRUGS USED TO TREAT HYPERTENSION
There are many drugs that can be used to treat hypertension . Most of these
drugs could also be used to treat other cardiovascular diseases as such as CHF,
angina, and dysrhythmias because of where they work in the vasculature or in
the heart. In this section, the drugs will be examined for their ability to lower
blood pressure—but keep in mind the other potential uses of these medications.
Hypertension is a highly prevalent medical problem in the U.S. It is aggravated
by things such as obesity, stress, poor diet, and lack of exercise. Most people
suffer from primary hypertension —HTN not due to any one identifiable cause. A
small percentage of patients may have secondary HTN—caused by an adrenal
tumor, for example. In both cases, blood pressure is elevated above the
“recommended” level of 120/80—how much the elevation is will direct whether to
treat with drugs, and ...
[107]
August Feature Articles The British Hypertension Society The ...
[61,0 KB]
From [www.hbprca.com.au] Last viewed: 21.09.2006
August Feature Articles
The British Hypertension Society
The British Hypertension Society (BHS) is a society
much like our own with over 230 members formed with
the aim to promote the advancement of knowledge and
dissemination of information concerning the pathophysiology, epidemiology,
detection, investigation and treatment of arterial hypertension and related vascular
diseases with in the United Kingdom. They provide a medical and scientific research
forum to enable sharing of cutting edge research in order to understand the origin of
high blood pressure and improve its treatment.
The BHS formed in the early 1980’s has a strong track record of producing
internationally renowned guidelines for the management of hypertension which are
widely adopted in primary care in the UK and elsewhere. As part of our increasing
engagement in improving blood pressure measurement they are now undertaking ...
[108]
2005 Canadian Hypertension Education Program Recommendations
[409,4 KB]
From [www.lipidnurse.ca] Last viewed: 21.09.2006
1
2005 Canadian Hypertension Education Program Recommendations
:
The sound bite version
On behalf of the Evidence-Based Recommendations Task Force of the
Canadian Hypertension Education Program
Page 2
2
2005 marks the sixth consecutive year that the Canadian Hypertension Education Program
has updated recommendations for the management of hypertension . This year we have
focused on the evidence supporting expedited assessment of both the hypertension -related
risk of atherosclerotic disease as well as a more “global” atherosclerotic risk assessment. In
addition, the 2005 recommendations support the increasingly held belief that, in the choice of
antihypertensive drugs, consideration of the effectiveness of blood pressure control
supersedes consideration of “pleiotropic” effects for the 5 major antihypertensive classes.
The new key messages identified ...
[109]
Pioglitazone Prevents Hypertension and Reduces Oxidative Stress in ...
[775,0 KB]
From [www.evms.edu] Last viewed: 21.09.2006
Pioglitazone Prevents Hypertension and Reduces Oxidative
Stress in Diet-Induced Obesity
Anca D. Dobrian, Suzanne D. Schriver, Ali A. Khraibi, Russell L. Prewitt
Abstract —The objective of this study was to determine the effect of pioglitazone on blood pressure (BP) and oxidative
balance in obese, hypertensive, Sprague-Dawley rats and to identify some of the molecular mechanisms involved. After
12 weeks of a moderately high-fat diet, rats diverged into obesity-prone (OP) and obesity-resistant (OR) groups (n 6
per group). At the end of the diet, peroxisome proliferator activated receptor- (PPAR ) mRNA expression and activity
in the renal cortex and medulla of OP rats were significantly lower compared with that in OR rats. Pioglitazone treatment
increased PPAR expression and activity in OP rats, suggesting a possible direct ligand-related effect of pioglitazone.
As opposed to the untreated OP group, which showed moderate ...
[110]
High Blood Pressure (Hypertension)
[273,3 KB]
From [wellness.uwsp.edu] Last viewed: 21.09.2006
This document was prepared by the staff of the UWSP University Health Service.
This information should not be used in lieu of medical care.
Last updated: November 2004
Hypertension .doc
High Blood Pressure ( Hypertension )
What is Hypertension ?
Hypertension , often called high blood pressure,
occurs when blood moving through your arteries
places too much force against the artery walls. A
person is told they have high blood pressure if
their blood pressure readings are repeatedly
above normal for a long time.
What do the Numbers Mean?
The top (first) number is the systolic pressure .
This is the pressure in the arteries when the
heart contracts. The bottom (second) number is
the diastolic pressure. This is the pressure in
the arteries when the heart relaxes and refills
between each heartbeat.
Table 1:
Classification of Blood Pressure ...
[111]
Hypertension ENGLISH Acordia.xls
[132,6 KB]
From [www.americanhealthcare.com] Last viewed: 21.09.2006
Hypertension
BMI
Perc
ent
a
ge
20
25
30
35
40
20
10
30
50
40
60
Relationship between BMI and crude percentage of women reporting
medical problems, surgical procedures, symptoms, and health care utilization.
Brown WJ et al. Int J Obes 1998;22:520-528.
Page 2
BMI
Perc
ent
a
ge
20
25
30
35
40
0
10
5
15
Diabetes
Brown WJ et al. Int J Obes 1998;22:520-528
.
Relationship between BMI and crude percentage of women reporting
medical problems, surgical procedures, symptoms, and health care utilization.
Page 3
BMI
Perc
ent
a
ge
20
25
30
35 ...
[112]
Chapter HYPERTENSION
[183,8 KB]
From [www.epi.umn.edu] Last viewed: 21.09.2006
Stang J, Story M (eds) Guidelines for Adolescent Nutrition Services (2005)
125
http://www.epi.umn.edu/let/pubs/adol_book.shtm
Chapter
11
HYPERTENSION
Irene Alton
Essential, or primary hypertension is a persistent elevation of blood pressure which is not caused
by underlying cardiac, endocrine, or renal disease.
1
Approximately 70% of blood pressure
elevations in youth represent early onset of essential hypertension .
1,2
• Adolescents 17 years of age or younger are considered to be hypertensive if their average
systolic and/or diastolic blood pressure measurements on three visits are at or above the 95th
percentile for age, gender and height (Tables 1, 2, 3).
3
• Adult standards are used to evaluate blood pressure elevations in adolescents who are 18
years or older (Table 4).
4
An average of at least ...
[113]
EXERCISE AND HYPERTENSION
[98,1 KB]
From [www.eshonline.org] Last viewed: 21.09.2006
Physical inactivity and hypertension
Cardiovascular diseases (CVDs) account for a large proportion of
mortality in adults older than 45 years. Numerous risk factors for
CVD including hypertension , diabetes, obesity and hypercholes-
terolemia are suspected to be influenced by fitness, and these fac-
tors may mediate the association between low fitness and mortal-
ity (1-2). Physical inactivity is strongly positively associated with
hypertension . Although the evidence from observational studies is
strong for an inverse relationship between physical activity level
and blood pressure (BP), these studies are limited by the inability
to ensure that all other factors that affect BP are the same
between active and non-active groups. Young adults with low fit-
ness were 3-to-6 fold more likely to develop diabetes, hyperten-
sion and the metabolic syndrome than those with high fitness (3).
Benefits of physical ...
[114]
HYPERTENSION AND ARRHYTHMIA
[102,4 KB]
From [www.eshonline.org] Last viewed: 21.09.2006
Introduction
Arrhythmia-both atrial and ventricular-is a common comorbidity
with hypertension (HT). Underlying mechanisms are many and
various, including left ventricular hypertrophy (LVH), myocardial
ischemia, impaired left ventricular function and left atrial enlarge-
ment. Any form of arrhythmia may be associated with LVH but
ventricular arrhythmia is more common as well as being more
dangerous.
Atrial arrhythmia
Prevalence
After supraventricular extrasystole, atrial fibrillation (AF) is the
next most common form of arrhythmia associated with HT. The
relative risk of developing AF in HT is modest compared with other
conditions, such as heart failure and valve disease. Nevertheless,
HT is the most prevalent, independent, and potentially modifiable
risk for AF (1). AF is most common after the age of 65 and in men
(2).
Mechanisms
Changes in atrial electrical properties occur early ...
[115]
NYBC Hypertension '05
[53,8 KB]
From [www.nybloodcenter.org] Last viewed: 21.09.2006
Why is it important to know
about hypertension ?
Hypertension means ‘high blood pressure’.
It is a major cause of heart disease, stroke
and kidney disease. About 50% of people who
have a heart attack and 66% who have a stroke have
hypertension . About one in four adults
has hypertension , but only about one-third
of those are aware that their blood pressure
is high. In fact, hypertension usually doesn’t
have any warning signs and has been called
"the silent killer." But fortunately, treatment
is available and effective.
Who is likely to develop hypertension ?
What are the risk factors?
• Age (over 35)
• Excessive weight
• Physical inactivity
• Family history of hypertension
• Diabetes, gout and kidney diseases
• Excessive salt intake
• Excessive alcohol intake
• Pregnancy
• Race - African-Americans are at higher ...
[116]
Pulmonary hypertension
[292,8 KB]
From [www.smw.ch] Last viewed: 21.09.2006
Pulmonary hypertension
Laurent P. Nicod
Pulmonary division, University Hospital, Geneva, Switzerland
Pulmonary arterial hypertension (PAH) has
often been misdiagnosed in the past, due to the
poor specificity of symptoms early in the disease
until the appearance of right heart failure. Al-
though primary pulmonary hypertension (PPH)
remains a rare disease, in recent times PAH related
to other diseases has been better recognised. These
forms are related to systemic connective tissue dis-
eases, thromboembolic disease, congenital heart
disease, portal hypertension or HIV infection, or
are secondary to the use of drugs as anorexigens.
They all result in an indistinguishable histological
picture [1, 2].
Improved understanding of the pathogenesis
of PPH has produced new treatments, not only for
PPH but for PAH related to other diseases. Ge-
netic predisposition has been found ...
[117]
Hypertension Research in Perth Neurocardiology Research Group ...
[139,4 KB]
From [www.hbprca.com.au] Last viewed: 21.09.2006
Hypertension Research in Perth
This month’s article focuses on Hypertension Research in our most Western
Capitol, Perth. We have contributions from three groups at the Royal Perth
Hospital. Founded in 1829, the 855 bed hospital admits over 67,000 patients
per year performing nearly 16,000 operations annually. It is not surprising
then that RPH is a major teaching and research Hospital in Western
Australia. The Hospital has a close association with the School of Medicine
at the University of Western Australia, and with other state universities
involved in the training of nursing and other health professionals. Its research
output is outstanding with over 150 articles per year. There is also a great contribution from Jackie Philips now
at the School of Veterinary and Biomedical Sciences at Murdoch University.
Neurocardiology Research Group : Royal Perth Hospital
Professor Leonard Arnolda ...
[118]
CYCLOSPORIN-INDUCED HYPERTENSION
[57,5 KB]
From [www.eshonline.org] Last viewed: 21.09.2006
CYCLOSPORIN-INDUCED HYPERTENSION
Renata Cífková, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; and Hermann Haller,
Medizinische Hochschule Hannover, Hannover, Germany
Introduction: Hypertension has emerged as a serious
adverse effect of immunosuppression with cyclosporin, which
has become the mainstay of immunosuppression in organ
transplantation. Improved survival rates with cyclosporin com-
pared to previous regimens based on corticosteroids and aza-
thioprine were established and have led to an expansion of
solid organ transplantation. Cyclosporin has also been used at
lower dosages for the treatment of autoimmune disease.
Cyclosporin is a macrolide antibiotic structurally different from
the newer immunosuppressive agent tacrolimus, although
both share final pathways that inhibit cytokine release from
lymphocytes. Both cyclosporin and tacrolimus induce wide- ...
[119]
RESISTANT HYPERTENSION
[30,6 KB]
From [www.eshonline.org] Last viewed: 21.09.2006
ESH
Definition and Prevalence
Hypertension is still a major health problem affect-
ing approximately 30% of the population by the age
of 60 years. 10% of the hypertensive patients
appear resistant to therapy (1,2). Resistant hyper-
tension is defined as failure of concomitant use of
three or more different antihypertensive agents to
lower blood pressure to less than 140/90 mmHg (3)
in all age groups. Older studies estimated the preva-
lence of refractory hypertension in tertiary care cen-
ters to be between 5 and 18 % (4-9). In a large
cohort study Alderman et al. found that only 2.9%
were resistant to antihypertensive therapy (10).
Recent clinical trials suggest that resistant hyper-
tension is increasingly common. ALLHAT
(Antihypertensive and Lipid Lowering Treatment to
Prevent Heart Attack) Study results indicate a high-
er prevalance. Among 14722 patients above 55
years, ...
[120]
HYPERTENSION IN CHILDREN AND ADOLESCENTS
[65,5 KB]
From [www.eshonline.org] Last viewed: 21.09.2006
and parenchymal diseases. More specifically, umbilical artery
catheter-associated thromboembolism affecting either the
aorta and/or the renal arteries probably accounts for the major-
ity of cases of hypertension seen in the typical neonatal inten-
sive care unit (4).
In very young children (<6 years), hypertension is most
often the result of such renal parenchymal disease as
glomerulonephritis, renal scarring, polycystic kidney diseases,
and renal dysplasia. Renal artery stenosis and cardiovascular
disorders like coarctation of the aorta, less frequent causes of
hypertension in this age group, are usually detected within the
first decade of life.
Late in the first decade and throughout the second, essen-
tial hypertension becomes the most common cause of sus-
tained hypertension , particularly in those children with mild
asymptomatic disease. In this age group, a predominance of
isolated ...